Parental obesity programs pancreatic cancer development in offspring

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Maternal obesity at conception programs obesity in the offspring.

Risk of obesity in adult life is subject to programming during gestation. To examine whether in utero exposure to maternal obesity increases the risk of obesity in offspring, we developed an overfeeding-based model of maternal obesity in rats utilizing intragastric feeding of diets via total enteral nutrition. Feeding liquid diets to adult female rats at 220 kcal/kg(3/4) per day (15% excess cal...

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Parental Obesity and Early Childhood Development.

BACKGROUND Previous studies identified associations between maternal obesity and childhood neurodevelopment, but few examined paternal obesity despite potentially distinct genetic/epigenetic effects related to developmental programming. METHODS Upstate KIDS (2008-2010) recruited mothers from New York State (excluding New York City) at ∼4 months postpartum. Parents completed the Ages and Stage...

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Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies.

Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and metabolic disease. Carefully controlled studies in precocial and altricial mammalian species provide insights into the involved mechanisms. These include programming of hypothalamic appetite-regulating centers to increase orexigenic relative to anorexigenic drive; increasing maternal, fetal, and offspri...

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Association of Parental Obesity With Concentrations of Select Systemic Biomarkers in Nonobese Offspring

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ژورنال

عنوان ژورنال: Endocrine-Related Cancer

سال: 2019

ISSN: 1351-0088,1479-6821

DOI: 10.1530/erc-19-0016